I/LWEQ domain
SMART accession number:SM00307
Description: Thought to possess an F-actin binding function.
Interpro abstract (IPR002558): I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin P26039 and yeast Sla2p P33338 interact with F-actin [(PUBMED:9159132)]. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [(PUBMED:9159132)]. I/LWEQ domains can be placed into four major groups based on sequence similarity:
  1. Metazoan talin.
  2. Dictyostelium discoideum (Slime mould) TalA/TalB.
  3. Metazoan Huntingtin-interacting protein-1 related (HIP1R) [(PUBMED:16415883)].
  4. Saccharomyces cerevisiae Sla2p.
GO function:actin binding (GO:0003779)
Family alignment:
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There are 546 ILWEQ domains in 546 proteins in SMART's nrdb database.

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