The domain within your query sequence starts at position 266 and ends at position 394; the E-value for the JmjC domain shown below is 5.07e-3.



A domain family that is part of the cupin metalloenzyme superfamily.
SMART accession number:SM00558
Description: Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).
Interpro abstract (IPR003347):

The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [(PUBMED:10838566), (PUBMED:11165500)].

Proteins containing JmjC domain are predicted to be metalloenzymes that adopt the cupin fold and are candidates for enzymes that regulate chromatin remodelling [(PUBMED:11165500)]. The cupin fold is a flattened beta-barrel structure containing two sheets of five antiparallel beta strands that form the walls of a zinc-binding cleft. Based on the crystal structure of JmjC domain containing protein FIH and JHDM3A/JMJD2A, the JmjC domain forms an enzymatically active pocket that coordinates Fe(III) and alphaKG. Three amino-acid residues within the JmjC domain bind to the Fe(II) cofactor and two additional residues bind to alphaKG [(PUBMED:16983801)].

JmjC domains were identified in numerous eukaryotic proteins containing domains typical of transcription factors, such as PHD, C2H2, ARID/BRIGHT and zinc fingers [(PUBMED:11165500), (PUBMED:12446723)]. The JmjC has been shown to function in a histone demethylation mechanism that is conserved from yeast to human [(PUBMED:16362057)]. JmjC domain proteins may be protein hydroxylases that catalyse a novel histone modification [(PUBMED:15809658)]. The human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation [(PUBMED:20739293)].

Family alignment:
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There are 36166 JmjC domains in 36140 proteins in SMART's nrdb database.

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