Ki-ras-induced actin-interacting protein-IP3R-interacting domain
SMART accession number:SM01257
Description: This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein) (PUBMED:14673706). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells (PUBMED:14673706). It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function (PUBMED:21501587).
Family alignment:
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There are 388 KRAP_IP3R_bind domains in 388 proteins in SMART's nrdb database.

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