SMART accession number:SM00505
Description: Knottins, representing plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins and arthropod defensins.
Interpro abstract (IPR003614):

Proteins containing the knottin domain are restricted to the eukaryota. They are known as knottins or cystine-knot peptides and consists of small inhibitors, toxins and lectins


The scorpion toxin-like domain constitutes a subgroup, found in metazoan sequences mainly from the arthropoda, which include the antibacterial defensins and the scorpion alpha-neurotoxins. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha -amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I.

GO process:defense response (GO:0006952)
Family alignment:
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There are 1385 Knot1 domains in 1333 proteins in SMART's nrdb database.

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