Sphingolipid Delta4-desaturase (DES)
SMART accession number:SM01269
Description: Sphingolipids are important membrane signalling molecules involved in many different cellular functions in eukaryotes. Sphingolipid delta 4-desaturase catalyses the formation of (E)-sphing-4-enine (PUBMED:11937514). Some proteins in this family have bifunctional delta 4-desaturase/C-4-hydroxylase activity. Delta 4-desaturated sphingolipids may play a role in early signalling required for entry into meiotic and spermatid differentiation pathways during Drosophila spermatogenesis (PUBMED:119375141). This small domain associates with FA_desaturase (PFAM PF00487) and appears to be specific to sphingolipid delta 4-desaturase.
Family alignment:
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There are 519 Lipid_DES domains in 519 proteins in SMART's nrdb database.

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