MAPKK1_Int

Mitogen-activated protein kinase kinase 1 interacting
MAPKK1_Int
SMART accession number:SM01278
Description: Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer PMID:15263099.
Interpro abstract (IPR015019): Ragulator complex protein LAMTOR3 (for lysosomal adaptor and MAPK and MTOR activator 3) is a regulator of the TOR pathway, which is a signalling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids [(PUBMED:19539012)].
GO process:regulation of TOR signaling (GO:0032006)
Family alignment:
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There are 566 MAPKK1_Int domains in 564 proteins in SMART's nrdb database.

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