 MGSMGS-like domain | |
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| SMART ACC: | SM000851 |
| Description: | This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site (PUBMED:10526357). |
| InterPro ACC: | IPR011607 |
| InterPro abstract: | Methylglyoxal synthase (MGS, EC:4.2.3.3 ), which catalyses the conversion of dihydroxyacetone phosphate (DHAP) to methylglyoxal (MG) and inorganic phosphate, has been found in many organisms, including enteric bacteria, some gram-positive bacteria, a number of archaebacteria, several yeast species and goat liver [ expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 47 239 MGS domains in 47 236 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing MGS domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing MGS domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Interaction (with the environment) |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a MGS domain which could be assigned to a KEGG orthologous group, and not all proteins containing MGS domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.