Matrilin_ccoil

Trimeric coiled-coil oligomerisation domain of matrilin
Matrilin_ccoil
SMART accession number:SM01279
Description: This short domain is a coiled coil structure and has a single cysteine residue at the start which is likely to form a di-sulfide bridge with a corresponding cysteine in an upstream EGF (SM00181) domain thereby spanning a VWA (SM00327) domain. All three domains can be associated together as in the cartilage matrix protein matrilin, where this domain is likely to be responsible for oligomerisation PMID:9287130.
Interpro abstract (IPR019466):

This entry represents a short domain found the matrilin (cartilage matrix) proteins. It forms a coiled coil structure and contains a single cysteine residue at its start which is likely to form a di-sulphide bridge with a corresponding cysteine in an upstream EGF domain, thereby spanning the VWA domain of the protein (IPR002035).This domain is likely to be responsible for protein trimerisation [(PUBMED:9287130), (PUBMED:9260286)].

Family alignment:
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There are 1789 Matrilin_ccoil domains in 1789 proteins in SMART's nrdb database.

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