Transcription mediator complex subunit Med12
SMART accession number:SM01281
Description: Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator PMID:15175151.
Family alignment:
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There are 553 Med12 domains in 553 proteins in SMART's nrdb database.

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