MltA

MltA specific insert domain

• SMART accession number: SM00925
• Description: This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.
• Interpro abstract (IPR005300):

  Escherichia coli MltA is a membrane-bound lytic transglycosylase comprised of two domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, which correspond to the 3D domain, named for 3 conserved aspartate residues. Domain B is inserted within the linear sequence of domain A [ (PUBMED:16139297) (PUBMED:16618494) (PUBMED:17502382) ].

  MltA is a membrane-bound, murein degrading transglycosylase enzyme that plays an important role in the controlled growth of the stress-bearing sacculus of E. coli [ (PUBMED:10037771) (PUBMED:9287002) ].

• GO function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)

There are 6585 MltA domains in 6585 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Cellular role: interaction

Structure (3D structures containing this domain)

3D Structures of MltA domains in PDB

PDB code	Title
2ae0	Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold
2g5d	Crystal structure of MltA from Neisseria gonorrhoeae Monoclinic form
2g6g	Crystal structure of MltA from Neisseria gonorrhoeae
2gae	Crystal structure of MltA from E. coli
2pi8	Crystal structure of E. coli MltA with bound chitohexaose
2pic	E. coli lytic transglycosylase MltA-D308A in apo-2 form
2pjj	E. coli lytic transglycosylase MltA-D308A in apo-1 form
2pnw	Crystal structure of membrane-bound lytic murein transglycosylase from Agrobacterium tumefaciens
3czb	Crystal structure of putative transglycosylase from Caulobacter crescentus

Links (links to other resources describing this domain)

• PFAM: MltA
• INTERPRO: IPR005300