Mob1/phocein family
SMART accession number:SM01388
Description: Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature (PMID:9436989). This family also includes phocein Q9QYW3 a rat protein that by yeast two hybrid interacts with striatin (PMID:11251078).
Family alignment:
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There are 1822 Mob1_phocein domains in 1820 proteins in SMART's nrdb database.

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