COMPASS (Complex proteins associated with Set1p) component N
SMART accession number:SM01291
Description: The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes PMID:11805083. This domain promotes trimethylation in conjunction with an RRM domain PMID:15775977and is necessary for binding of the Spp1 component of COMPASS into the complex PMID:16921172.
Family alignment:
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There are 515 N-SET domains in 515 proteins in SMART's nrdb database.

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