C2 domain of PTEN tumour-suppressor protein
SMART accession number:SM01326
Description: This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane (PMID:10555148).
Family alignment:
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There are 1569 PTEN_C2 domains in 1566 proteins in SMART's nrdb database.

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