The domain within your query sequence starts at position 112 and ends at position 203; the E-value for the PUA domain shown below is 1.96e-4.
GEVIVGAQCGNAVLRGAHVYVPGIVSASKFMKAGDVISVYSDINGKCKKGAKEFDGTKVF LGNGISELSRKDIFNGLPDLKGIGIRMTEPIY
PUAPutative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase |
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SMART accession number: | SM00359 |
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Description: | - |
Interpro abstract (IPR002478): | The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found [(PUBMED:10093218)]. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [(PUBMED:16793063), (PUBMED:16407303)]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA [(PUBMED:17803682)]. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases [(PUBMED:16943774)]. |
GO function: | RNA binding (GO:0003723) |
Family alignment: |
There are 27311 PUA domains in 27309 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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