ACCA

 ACCA
PFAM accession number:PF03255
Interpro abstract (IPR001095):

This entry contains the alpha subunit the acetyl coenzyme A carboxylase complex ( EC 6.4.1.2 ). It catalyses the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [ (PUBMED:1355089) ]. The reaction involves two steps:

Biotin carrier protein + ATP + HCO 3 - -> Carboxybiotin carrier protein + ADP + P i Carboxybiotin carrier protein + Acetyl-CoA -> Malonyl-CoA + Biotin carrier protein
GO process:fatty acid biosynthetic process (GO:0006633)
GO component:acetyl-CoA carboxylase complex (GO:0009317)
GO function:acetyl-CoA carboxylase activity (GO:0003989)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry ACCA