The domain within your query sequence starts at position 227 and ends at position 457; the E-value for the ALS2CR8 domain shown below is 6.4e-63.
YGPRRKGFQLKKISEQESRSCHLYKATCPARIYIKKVQKFPEYRVPTDPQIDRKIIRLEQ EKAFTMLKKNLMDAGGVLRWYVQLPTQQAHQYHESETPGVPLSPSPFPMSPLEEEEAIVR DENCALPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEIPERHNLSYFP TVNDIKNHIHEVQKSLRTGDVVYNSEIIPATLQWTTDSGNILRETVTVTFA
ALS2CR8 |
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PFAM accession number: | PF15299 |
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Interpro abstract (IPR029309): | This entry represents calcium-responsive transcription factor (CaRF, also known as amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) [ (PUBMED:11832226) ]. CaRF acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. It binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence [ (PUBMED:11832226) ]. |
GO process: | positive regulation of transcription from RNA polymerase II promoter in response to calcium ion (GO:0061400) |
GO function: | DNA-binding transcription factor activity (GO:0003700) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry ALS2CR8