The domain within your query sequence starts at position 227 and ends at position 457; the E-value for the ALS2CR8 domain shown below is 6.4e-63.

YGPRRKGFQLKKISEQESRSCHLYKATCPARIYIKKVQKFPEYRVPTDPQIDRKIIRLEQ
EKAFTMLKKNLMDAGGVLRWYVQLPTQQAHQYHESETPGVPLSPSPFPMSPLEEEEAIVR
DENCALPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEIPERHNLSYFP
TVNDIKNHIHEVQKSLRTGDVVYNSEIIPATLQWTTDSGNILRETVTVTFA

ALS2CR8

ALS2CR8
PFAM accession number:PF15299
Interpro abstract (IPR029309):

This entry represents calcium-responsive transcription factor (CaRF, also known as amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) [ (PUBMED:11832226) ]. CaRF acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. It binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence [ (PUBMED:11832226) ].

GO process:positive regulation of transcription from RNA polymerase II promoter in response to calcium ion (GO:0061400)
GO function:DNA-binding transcription factor activity (GO:0003700)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry ALS2CR8