The domain within your query sequence starts at position 239 and ends at position 339; the E-value for the ANAPC5 domain shown below is 3.5e-34.

HYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAEGKSNGEEGYGRSLRYAALNLAALHCR
FGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKR

ANAPC5

ANAPC5
PFAM accession number:PF12862
Interpro abstract (IPR026000):

This entry represents a domain found in Apc5 (anaphase-promoting complex subunit 5).

Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multisubunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1. Tetratricopeptide repeat protein 19 is a mitochondrial protein required for formation of the mitochondrial complex III [ (PUBMED:21278747) ].

Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [ (PUBMED:15082755) (PUBMED:16896351) ]. The N terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC [ (PUBMED:19584054) ]. This region of the Apc5 member proteins carries a TPR-like motif.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry ANAPC5