Aldolase

• PFAM accession number: PF01081
• Interpro abstract (IPR000887):

  4-Hydroxy-2-oxoglutarate aldolase ( EC 4.1.3.16 ) (KHG-aldolase) catalyzes the interconversion of 4-hydroxy-2-oxoglutarate into pyruvate and glyoxylate. Phospho-2-dehydro-3-deoxygluconate aldolase ( EC 4.1.2.14 ) (KDPG-aldolase) catalyzes the interconversion of 6-phospho-2-dehydro-3-deoxy-D-gluconate into pyruvate and glyceraldehyde 3-phosphate. E. coli Eda is a KDPG-aldolase that has also been found to have a role in the degradation of 2-keto-4-hydroxyglutarate (KHG) to pyruvate and glyoxylate [ (PUBMED:4894280) ]. In fact, KHG-aldolase and Eda are the same enzyme [ (PUBMED:15659677) ].

  This family consists of KHG/KDPG aldolases, and also includes 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase. KDPGal-aldolase catalyzes an identical reaction to KDPG, differing in substrate specificity in only the configuration of a single stereocentre [ (PUBMED:17981470) ].

• GO function: lyase activity (GO:0016829)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Aldolase