The domain within your query sequence starts at position 40 and ends at position 141; the E-value for the Anoctamin domain shown below is 5.7e-24.



PFAM accession number:PF04547
Interpro abstract (IPR007632):

This entry represents the anoctamin family, which includes anoctamin1-10 (Ano1-10 or TMEM16A-J); 7 members could be divided into two subfamilies, Ca(2+)-dependent Cl(-) channels (TMEM16A and 16B) and Ca(2+)-dependent lipid scramblases (TMEM16C, 16D, 16F, 16G, and 16J) [(PUBMED:23532839)]. This entry also includes anoctamin-like protein At1g73020 from Arabidopsis and increased sodium tolerance protein 2 (Ist2) from budding yeasts.

Ano1 and Ano2 (also known as TMEM16A and TMEM16B) are calcium-activated chloride channels (CaCC), which play a role in transepithelial anion transport and smooth muscle contraction [(PUBMED:18724360), (PUBMED:19474308)]. Ano3-10 do not exhibit calcium-activated chloride channel (CaCC) activity [(PUBMED:17308099), (PUBMED:20056604)].

Ist2 may be involved in ion homeostasis together with BTN1 or BTN2 [(PUBMED:15701790)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Anoctamin