BcsB

• PFAM accession number: PF03170
• Interpro abstract (IPR018513):

  An operon encoding 4 proteins required for bacterial cellulose biosynthesis (bcs) in Acetobacter xylinus (Gluconacetobacter xylinus) has been isolated via genetic complementation with strains lacking cellulose synthase activity [ (PUBMED:2146681) ]. Nucleotide sequence analysis showed the cellulose synthase operon to consist of 4 genes, designated bcsA, bcsB, bcsC and bcsD, all of which are required for maximal bacterial cellulose synthesis in A. xylinum.

  The calculated molecular mass of the protein encoded by bcsB is 85.3kDa [ (PUBMED:2146681) ]. BcsB encodes the catalytic subunit of cellulose synthase. The protein polymerises uridine 5'-diphosphate glucose to cellulose: UDP-glucose + (1,4-beta-D-glucosyl)(N) = UDP + (1,4-beta-D-glucosyl)(N+1). The enzyme is specifically activated by the nucleotide cyclic diguanylic acid. Sequence analysis suggests that BcsB contains several transmembrane (TM) domains, and shares a high degree of similarity with Escherichia coli YhjN.

• GO process: UDP-glucose metabolic process (GO:0006011)
• GO component: membrane (GO:0016020)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry BcsB