SMART: Pfam domain Bromodomain

The domain within your query sequence starts at position 191 and ends at position 234; the E-value for the Bromodomain domain shown below is 1.1e-9.

MYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEK

Bromodomain

PFAM accession number:	PF00439
Interpro abstract (IPR001487):	Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [ (PUBMED:1350857) ]. Bromodomains can interact with acetylated lysine [ (PUBMED:9175470) ]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate. The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [ (PUBMED:7580139) ].
GO function:	protein binding (GO:0005515)

PFAM accession number:

PF00439

Interpro abstract (IPR001487):

Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [ (PUBMED:1350857) ]. Bromodomains can interact with acetylated lysine [ (PUBMED:9175470) ]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [ (PUBMED:7580139) ].

GO function:

protein binding (GO:0005515)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Bromodomain