The domain within your query sequence starts at position 21 and ends at position 290; the E-value for the CAML domain shown below is 8.8e-143.



PFAM accession number:PF14963
Interpro abstract (IPR016719):

This group represents a calcium signal-modulating cyclophilin ligand (CAML). Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A [(PUBMED:18635947)]. The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin. CAML acts downstream of the TCR and upstream of calcineurin by causing an influx of calcium [(PUBMED:7522304)].

The HIV-1 Vpu protein is required for efficient viral release from human cells. CAML is a Vpu-interacting host factor that restricts HIV-1 release. CAML is probably the mechanistic link between the two viral regulators Vpu and HIV-2 Env [(PUBMED:18500349)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CAML