SMART: Pfam domain CAS

The domain within your query sequence starts at position 527 and ends at position 962; the E-value for the CAS_CSE1 domain shown below is 1.1e-181.

ERLFTMRGSNNTTLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEA
IIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFL
VFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVR
LLQAFLERGSSTIATAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQY
RKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKII
IPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDSIPD
EEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSM
VSTSLNAEALQYLQGY

CAS_CSE1

PFAM accession number:	PF03378
Interpro abstract (IPR005043):	This entry represents the C-terminal domain of XPO2. Structural studies of its yeast homologue, Cse1, indicate that this domain binds to both the transport-orchestrating protein RanGTP and the cargo molecule that is being exported [ (PUBMED:15602554) ]. Exportin-2, also known as CAS, is an export receptor for importin-alpha [ (PUBMED:9323134) ]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [ (PUBMED:10394916) ].
GO function:	protein binding (GO:0005515), Ran GTPase binding (GO:0008536)

PFAM accession number:

PF03378

Interpro abstract (IPR005043):

This entry represents the C-terminal domain of XPO2. Structural studies of its yeast homologue, Cse1, indicate that this domain binds to both the transport-orchestrating protein RanGTP and the cargo molecule that is being exported [ (PUBMED:15602554) ].

Exportin-2, also known as CAS, is an export receptor for importin-alpha [ (PUBMED:9323134) ]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [ (PUBMED:10394916) ].

GO function:

protein binding (GO:0005515), Ran GTPase binding (GO:0008536)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CAS_CSE1