SMART: Pfam domain CBP

CBP_GIL

PFAM accession number:	PF10995
Interpro abstract (IPR017745):	BcsE (bacterial cellulose synthase E) or YhjS, is required for cellulose biosynthesis in Salmonella enteritidis. Its role is this process across multiple bacterial species is implied by the partial phylogenetic profiling algorithm. Members are found in the vicinity of other cellulose biosynthesis genes [ (PUBMED:11929533) ]. BcsE contains the C-terminal GIL domain. The GIL domain, for GGDEF I-site like domain, is a c-di-GMP binding domain on the BcsE proteins of enterobacteria. It is not essential for cellulose synthesis but is critical for maximal cellulose production. Cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA. The RxGD motif of the GIL domain is required for c-di-GMP binding [ (PUBMED:24942809) ].
GO function:	cyclic-di-GMP binding (GO:0035438)

PFAM accession number:

PF10995

Interpro abstract (IPR017745):

BcsE (bacterial cellulose synthase E) or YhjS, is required for cellulose biosynthesis in Salmonella enteritidis. Its role is this process across multiple bacterial species is implied by the partial phylogenetic profiling algorithm. Members are found in the vicinity of other cellulose biosynthesis genes [ (PUBMED:11929533) ].

BcsE contains the C-terminal GIL domain. The GIL domain, for GGDEF I-site like domain, is a c-di-GMP binding domain on the BcsE proteins of enterobacteria. It is not essential for cellulose synthesis but is critical for maximal cellulose production. Cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA. The RxGD motif of the GIL domain is required for c-di-GMP binding [ (PUBMED:24942809) ].

GO function:

cyclic-di-GMP binding (GO:0035438)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CBP_GIL