The domain within your query sequence starts at position 264 and ends at position 364; the E-value for the CC2-LZ domain shown below is 5.5e-12.
HAQLKRRQVPLEPELMKKEISRLNRQLEEKISDCAEANQELTAMRMSRDTALERVQMLEQ QILAYKDDFKSERADRERAHSRIQELEEKIMSLMYQVSQRQ
CC2-LZ |
---|
PFAM accession number: | PF16516 |
---|---|
Interpro abstract (IPR032419): | NF-kappa-B essential modulator NEMO comprises two coiled-coil regions, denoted as CC1 and CC2, a leucine zipper (LZ), and a zinc finger (ZF). This entry represents the CC2-LZ domain that plays a regulatory role. It contains a ubiquitin-binding domain (UBD) and represents one region that contributes to NEMO oligomerisation. NEMO itself is an integral part of the IkappaB kinase complex and serves as a molecular switch via which the NF-kappaB signalling pathway is regulated [ (PUBMED:19854204) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry CC2-LZ