The domain within your query sequence starts at position 6 and ends at position 710; the E-value for the CCCAP domain shown below is < 1e-12.
GNSTLEDSLGQYQRSLRERANRSIHQLKCALREVDVTVEEDALDPSTSINVENEDTGVAW HELQHSHAVNQLKALLRQQTNKENETSPPRRRKLSPSRPSECDDGSMPTMHNLVPIINDQ SQYIHHLEAEVKFCKDELSGMKNRVQVVVLENERLQQELKSQRPEETLREQTFLDASGNM QNSWIMTREDSRVDEAAKRPFSHGDAETGKTASTGDANKWKLELERLKLTYEAKTDLLES QLMLLRKDLAEYQKTCEDLKERLKHKESLLAASASSRVGGLCLKCAQHEAVLSQTHSNVH IQTIERLTKERDDLMSVLVSVRSSLAEAQKRETSAYEQVKHAVQMTEEANFEKTKALIQC EQLKSELERQTERLEKELASQQEKRAVEKEMIKKEVAREREDAESKMLILSQNIAKLEAQ VEKVTREKTAAVSHLEEIQNHVASQEMDVTKVCGEMRFQLNKTKMEKDEVEKEHREYKAK SHKDLEMKVQEIEKLRLELSESEQHVEQEQQKAARARQECLRVTELLGEAERQLHLTRLE KDSIQQSFSNEAKAQALQAQQREQELTQKIQQMETQHDKTESEQYLLLTSQNTFLTKLKE ECCLLAKKLEKVSLKSRSQIVRLSQEKRYLCDKLEKLQKRNDELEEQCIQHGRVHETMKE RLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVARLRAQLP
CCCAP |
---|
PFAM accession number: | PF15964 |
---|---|
Interpro abstract (IPR031887): | Serologically defined colon cancer antigen 8 (SDCCAG8), also known as CCCAP (centrosomal colon cancer autoantigen protein), is a family of proteins found in eukaryotes. Mutations of SDCCAG8 are associated with nephronophthisis [ (PUBMED:20835237) ] and Bardet-Biedl syndrome [ (PUBMED:22626039) ], as well as schizophrenia. SDCCAG8 is associated with the centrosome [ (PUBMED:12559564) ] and interacts with pericentriolar material 1 (PCM1), a centriolar satellite protein crucial for targeting proteins to the centrosome. It regulates centrosomal accumulation of pericentriolar material and neuronal polarisation and migration in the developing mouse cortex [ (PUBMED:25088364) ]. SDCCAG8 is localized at both centrioles and interacts directly with OFD1 (oral-facial-digital syndrome 1), which is linked to an autosomal recessive cystic kidney disease, NPHP-RC (nephronophthisis-related ciliopathies). Depletion of SDCCAG8 causes kidney cysts and a body axis defect in zebrafish [ (PUBMED:20835237) ]. |
GO process: | centrosome cycle (GO:0007098) |
GO component: | centrosome (GO:0005813) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry CCCAP