The domain within your query sequence starts at position 1 and ends at position 517; the E-value for the CENP-I domain shown below is 1e-247.

MATQRVTRNSQQQNRISQGSNSRQTSLLDWMVKDKSGNFKSVLKESSSVEDSTRTDDRTE
GALQVAVGYFQKGPKKASLSKDKVLEKHLTTVENVALSNGLAPEAIDILLNVALSGKFGN
AVNSRILKCMIPESHISEDSVLKAVSWLCVDKCSGNTKVLFYRWLVAMFDFIDHKKQISS
LYGFFFASLQDDTLCPYVCHLLYLLTKRENVKPFRVRKLLDLQAKMGMQPHLQALLSLYK
FFAPTLISVSLPVRKKIFFNNSKNLWTSASLAVRLRNQGAFPEPLNLPLRPTTGRSLKRK
WNSHSVIPALNSANKEYGEKTASLFDYLSSERSLPLEQLQRFPQLLESIHCLELPSQMCS
VLNSPLLLHYINCVKDESILLRISYWLSQALQEECVWYNINNYEQEKEFINFLDLVIRVQ
CFLQEGFYSCEAFLYKSLPLWDGSSCRSQYLQLLAWIPFSSFSEVKPLLSDHLAPLFFTS
SIYFKCSVLQSLQELLQNWLLWLSTDAHVQPTTDSPL

CENP-I

• PFAM accession number: PF07778
• Interpro abstract (IPR012485):

  Centromere protein I (CENP-I) is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation [ (PUBMED:12640463) ]. It may be involved in incorporation of newly synthesized CENP-A into centromeres via its interaction with the CENPA-NAC complex [ (PUBMED:16622420) ]. In humans, CENP-I is required for the localisation of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores and is involved in the response of gonadal tissues to follicle-stimulating hormone [ (PUBMED:11970896) ].

  The CENP-I homologue in Schizosaccharomyces pombe, Mis6, is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant; an important event for centromere function and chromosome segregation during mitosis [ (PUBMED:9230309) (PUBMED:10864871) ].

• GO process: centromere complex assembly (GO:0034508)
• GO component: kinetochore (GO:0000776)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CENP-I