SMART: Pfam domain CENP-T

The domain within your query sequence starts at position 1 and ends at position 374; the E-value for the CENP-T_N domain shown below is 4.2e-174.

MADLSFSDGDPTVRTLLRRVLETADSRTPMRRRSTRINAQRRRSQTPYSNRQGSQTKTSA
RKQSHGARSVGRSTRVQGRGRLEEQTPRTLLRNILLTAPESSTVMPDPVVKPAQVPEVAR
SSRRESSRGSLELHLPELEPPSTLAPGLTAPGKRKQKLRLSVFQQEVDQGLPLSQEPRRS
RSADVSSLASSFNLTFVLPGQPETVERPGLARRRPIRQLVNAGALLQDLEDNSLASALPG
DSHRTPVAALPMDVGLEDTQPFSQSLAAFSLSGKHSLPSPSRPGVEDVERVMGPPSSGTR
LQSRMSRSGPAASPSPFLEPQPPPAEPREAVGSNEAAEPKDQEGSSGYEETSARPASGEL
SSSTHDSLPAEQPP

CENP-T_N

PFAM accession number:	PF16171
Interpro abstract (IPR032373):	Multiple proteins are assembled on centromeric DNA to form the kinetochore structure. CENP-T is a component of the constitutive centromere associated network (CCAN) of proteins that creates a platform for kinetochore formation. CENP-T associates directly with CENP-W. The N terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes [ (PUBMED:22391098) (PUBMED:21464230) (PUBMED:22304917) ]. This entry represents the N terminus of CENP-T.

PFAM accession number:

PF16171

Interpro abstract (IPR032373):

Multiple proteins are assembled on centromeric DNA to form the kinetochore structure. CENP-T is a component of the constitutive centromere associated network (CCAN) of proteins that creates a platform for kinetochore formation. CENP-T associates directly with CENP-W. The N terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes [ (PUBMED:22391098) (PUBMED:21464230) (PUBMED:22304917) ]. This entry represents the N terminus of CENP-T.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CENP-T_N