The domain within your query sequence starts at position 26 and ends at position 155; the E-value for the CLCA domain shown below is 6.4e-67.
IKLNENGYEDIIIAIDPAVPEDTTIIERMKEMVTKASTYLFEATEKRFFFKNVSILIPES WKDSPHYRRPKRESYKHADIKVAPPAFMGRDEPYTRQFTQCEEKAEYIHFTPDFVLGRKQ DEYGDSGGEF
CLCA |
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PFAM accession number: | PF08434 |
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Interpro abstract (IPR013642): | The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells [ (PUBMED:11896056) ] and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors [ (PUBMED:15284223) ]. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage [ (PUBMED:22350745) (PUBMED:23112050) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry CLCA