CM_1

• PFAM accession number: PF07736
• Interpro abstract (IPR008243):

  Chorismate mutase (CM) ( EC 5.4.99.5 ) catalyses the conversion of chorismate to prephenate in the shikimate pathway of tyrosine and phenylalanine biosynthesis in bacteria, fungi and plants [ (PUBMED:8378335) (PUBMED:17965159) ].

  The three types of CM are AroH class, AroQ class, prokaryotic type and AroQ class, eukaryotic type. Structurally CMs can be divided into two main groups: type I (AroH class) and type II (AroQ class). Type I (AroH) CMs include CMs characterised by a trimeric pseudo alpha/beta barrel structure [ (PUBMED:17965159) ]. The two types of the AroQ structural class (the Escherichia coli CM dimer and the yeast CM monomer) can be structurally superimposed, and the topology of the four-helix bundle forming the active site is conserved [ (PUBMED:11528003) ]. CMs can be monofunctional or bifunctional (generally fused to another shikimate pathway member). Despite the structural differences, all CMs perform the same basic reaction [ (PUBMED:17965159) ].

  This entry represents chorismate mutases of the AroH class predominantly from Terrabacteria.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CM_1