SMART: Pfam domain CWC25

The domain within your query sequence starts at position 64 and ends at position 147; the E-value for the CWC25 domain shown below is 3.3e-19.

KKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEREAGCSSETGLLPGSIFAPSG
ANSLLDMASKIREDPLFIIRYCWE

CWC25

PFAM accession number:	PF12542
Interpro abstract (IPR022209):	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with . There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.

PFAM accession number:

PF12542

Interpro abstract (IPR022209):

This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with . There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CWC25