SMART: Pfam domain CbtA

CbtA_toxin

PFAM accession number:	PF06755
Interpro abstract (IPR009610):	CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism [ (PUBMED:1459483) ]. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerisation, and for MreB it inhibits its ATP-dependent polymerisation. These actions of CbtA appear to occur simultaneously [ (PUBMED:21166897) ]. he cognate antitoxin family is represented by IPR009320 .

PFAM accession number:

PF06755

Interpro abstract (IPR009610):

CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism [ (PUBMED:1459483) ]. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerisation, and for MreB it inhibits its ATP-dependent polymerisation. These actions of CbtA appear to occur simultaneously [ (PUBMED:21166897) ]. he cognate antitoxin family is represented by IPR009320 .

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CbtA_toxin