The domain within your query sequence starts at position 3 and ends at position 349; the E-value for the CoA_transf_3 domain shown below is 1.6e-82.



PFAM accession number:PF02515
Interpro abstract (IPR003673):

CoA-transferases are found in organisms from all kingdoms of life. They catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids. There are at least three families of CoA-transferases, which differ in sequence and reaction mechanism:

  • Family I consists of CoA-transferases for 3-oxoacids ( EC EC ), short-chain fatty acids ( EC EC ) and glutaconate ( EC ). Most use succinyl-CoA or acetyl-CoA as CoA donors.
  • Family II consists of the homodimeric alpha-subunits of citrate lyase and citramalate lyase ( EC EC ). These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well.
  • Family III consists of formyl-CoA:oxalate CoA-transferase [ (PUBMED:15213226) ], succinyl-CoA:(R)-benzylsuccinate CoA-transferase [ (PUBMED:11418570) ], (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase [ (PUBMED:10849007) ], succinyl-CoA:mesaconate CoA-transferase [ (PUBMED:28932214) ] and butyrobetainyl-CoA:(R)-carnitine CoA-transferase [ (PUBMED:15823031) ]. These CoA-transferases occur in prokaryotes and eukaryotes, and catalyse CoA-transfer reactions in a highly substrate- and stereo-specific manner [ (PUBMED:11749953) ].

This entry represents family III CoA-transferases.

GO function:CoA-transferase activity (GO:0008410)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CoA_transf_3