The domain within your query sequence starts at position 257 and ends at position 358; the E-value for the Connexin40_C domain shown below is 8.3e-37.



PFAM accession number:PF16791
Interpro abstract (IPR031862):

This entry represents the C-terminal domain of connexin 40 (Cx40). It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop of another connexin 40 [(PUBMED:19808665)].

Connexin 40 is a gap junction protein that has been linked to lone atrial fibrillation [(PUBMED:24733048)]. Gap junctions is composed of two hemichannels, each constituted by the oligomerisation of six connexins (Cx). This junction allows direct exchange of ions and small molecules between apposing cells [(PUBMED:24733048)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Connexin40_C