The domain within your query sequence starts at position 1 and ends at position 113; the E-value for the DAD domain shown below is 8e-55.
MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGF ISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG
DAD |
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PFAM accession number: | PF02109 |
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Interpro abstract (IPR003038): | Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated [ (PUBMED:8413235) ], these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation (also known as Ost2) [ (PUBMED:7593165) ]. DAD1/Ost2 is a component of the N-oligosaccharyl transferase enzyme which catalyses the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [ (PUBMED:9167970) ]. |
GO component: | integral component of membrane (GO:0016021), oligosaccharyltransferase complex (GO:0008250) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry DAD