DHBP_synthase

• PFAM accession number: PF00926
• Interpro abstract (IPR000422):

  3,4-dihydroxy-2-butanone 4-phosphate synthase ( EC 4.1.99.12 ) (DHBP synthase) (RibB) catalyses the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate, the latter serving as the biosynthetic precursor for the xylene ring of riboflavin [ (PUBMED:9211332) ]. In Photobacterium leiognathi, the riboflavin synthesis genes ribB (DHBP synthase), ribE (riboflavin synthase), ribH (lumazone synthase) and ribA (GTP cyclohydrolase II) all reside in the lux operon [ (PUBMED:11396941) ]. RibB is sometimes found as a bifunctional enzyme with GTP cyclohydrolase II that catalyses the first committed step in the biosynthesis of riboflavin ( IPR000926 ). No sequences with significant homology to DHBP synthase are found in the metazoa.

• GO process: riboflavin biosynthetic process (GO:0009231)
• GO function: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity (GO:0008686)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DHBP_synthase