SMART: Pfam domain DHquinase

DHquinase_I

PFAM accession number:	PF01487
Interpro abstract (IPR001381):	3-dehydroquinate dehydratase ( EC 4.2.1.10 ), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. The best studied type I enzyme is from Escherichia coli (gene aroD) and related bacteria where it is a homodimeric protein. In fungi, dehydroquinase is part of a multifunctional enzyme which catalyses five consecutive steps in the shikimate pathway. A histidine [ (PUBMED:1429576) ] is involved in the catalytic mechanism. This entry represents the 3-dehydroquinate dehydratase, type I, either as a monofunctional protein or as a domain of a larger, multifunctional protein.
GO function:	3-dehydroquinate dehydratase activity (GO:0003855)

PFAM accession number:

PF01487

Interpro abstract (IPR001381):

3-dehydroquinate dehydratase ( EC 4.2.1.10 ), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. The best studied type I enzyme is from Escherichia coli (gene aroD) and related bacteria where it is a homodimeric protein. In fungi, dehydroquinase is part of a multifunctional enzyme which catalyses five consecutive steps in the shikimate pathway. A histidine [ (PUBMED:1429576) ] is involved in the catalytic mechanism.

This entry represents the 3-dehydroquinate dehydratase, type I, either as a monofunctional protein or as a domain of a larger, multifunctional protein.

GO function:

3-dehydroquinate dehydratase activity (GO:0003855)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DHquinase_I