SMART: Pfam domain DUF1213

DUF1213

PFAM accession number:	PF06740
Interpro abstract (IPR009603):	The Drosophila protein Futsch has homology to MAP1B and controls synaptic growth at the Drosophila neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Futsch protein colocalises with microtubules and identifies cytoskeletal loops that traverse the lateral margin of select synaptic boutons. Futsch mutations disrupt synaptic microtubule organisation, reduce bouton number, and increase bouton size. These deficits can be partially rescued by neuronal overexpression of a Futsch MAP1B homology domain [ (PUBMED:10839356) ]. The translation of Futsch is repressed by Fragile X mental retardation 1 (Fmr1), an RNA binding protein that acts as a negative translational regulator [ (PUBMED:11733059) ]. The N- and C-terminal domains of Futsch are homologous to the vertebrate MAP1B microtubule-associated protein. The central domain of Futsch is highly repetitive [ (PUBMED:10839355) ]. This entry represents the Futsch repeats.
GO process:	microtubule cytoskeleton organization (GO:0000226)

PFAM accession number:

PF06740

Interpro abstract (IPR009603):

The Drosophila protein Futsch has homology to MAP1B and controls synaptic growth at the Drosophila neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Futsch protein colocalises with microtubules and identifies cytoskeletal loops that traverse the lateral margin of select synaptic boutons. Futsch mutations disrupt synaptic microtubule organisation, reduce bouton number, and increase bouton size. These deficits can be partially rescued by neuronal overexpression of a Futsch MAP1B homology domain [ (PUBMED:10839356) ]. The translation of Futsch is repressed by Fragile X mental retardation 1 (Fmr1), an RNA binding protein that acts as a negative translational regulator [ (PUBMED:11733059) ].

The N- and C-terminal domains of Futsch are homologous to the vertebrate MAP1B microtubule-associated protein. The central domain of Futsch is highly repetitive [ (PUBMED:10839355) ]. This entry represents the Futsch repeats.

GO process:

microtubule cytoskeleton organization (GO:0000226)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF1213