The domain within your query sequence starts at position 7 and ends at position 283; the E-value for the DUF1669 domain shown below is 2.8e-111.

LSSLNDECRSDNYVEPHYKEWYRVAVDTLIEHGLEAYQEFLIKERVSDFLAEEEINYILK
NVQKIAQNTEHGSDSSCDDGSSSGTYWPMQSDVEAPNLDLGWPYVMPGLLGSTHIDLLFH
PPRAHLLTIKETIRKMIKEARKVVAIVMDVFTDVDIFKEIVEASTRGISVYILLDESNFS
HFLTMTEKQGCQIQRLRNIRIRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSY
MWSFEKAHLSMVQIITGHLVELFDEEFRTLYARSSVP

DUF1669

 DUF1669
PFAM accession number:PF07894
Interpro abstract (IPR012461):

FAM83 family members include FAM83A-H. They are oncogenes that function as intermediaries in EGFR/RAS signaling [(PUBMED:27221039)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF1669