The domain within your query sequence starts at position 46 and ends at position 297; the E-value for the DUF2464 domain shown below is 1.7e-87.

DPITGVGVVASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHL
GNVLVDMKLIDVKDTLPVGFIPIQETVDTQEVVFRKKRLCIKFIPRDSTEAAICDIRIMG
RTKQAPPQYTFIGELNSMGIWYRMGRVPRNHDSSQPTTPSQSSASSTPAPNLPRHISLTL
PATFRGRNNTSTDYEYQLSNLYAISAMDGVPFMISEKFSCIPESMQPFDLLGITIKSLAE
IEKEYEYSFRTE

DUF2464

DUF2464
PFAM accession number:PF10240
Interpro abstract (IPR018798):

MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle [ (PUBMED:20654576) (PUBMED:24284069) ]. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor [ (PUBMED:16895919) ].

GO component:ESCRT I complex (GO:0000813)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF2464