The domain within your query sequence starts at position 63 and ends at position 155; the E-value for the DUF3398 domain shown below is 4.7e-26.



PFAM accession number:PF11878
Interpro abstract (IPR021816):

DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [(PUBMED:12432077)]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [(PUBMED:25022758), (PUBMED:15723800)]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [(PUBMED:12432077)].

This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8), DOCK-D subfamily (DOCK 9, 10, 11).

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF3398