SMART: Pfam domain DUF4154

DUF4154

PFAM accession number:	PF13689
Interpro abstract (IPR025293):	YfiR has been shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates YfiN activity in response to reducing conditions [ (PUBMED:25849887) (PUBMED:27507823) ]. HmsC in Yersinia Pestis is the orthologue of YfiR from E. coli [ (PUBMED:25586342) ]. HmsC is a periplasmic protein that interacts directly with the periplasmic domain (PD) of HmsD and causes proteolytic degradation of HmsD, which in turn negatively regulates Y. pestis biofilm formation [ (PUBMED:24192006) ].

PFAM accession number:

PF13689

Interpro abstract (IPR025293):

YfiR has been shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates YfiN activity in response to reducing conditions [ (PUBMED:25849887) (PUBMED:27507823) ].

HmsC in Yersinia Pestis is the orthologue of YfiR from E. coli [ (PUBMED:25586342) ]. HmsC is a periplasmic protein that interacts directly with the periplasmic domain (PD) of HmsD and causes proteolytic degradation of HmsD, which in turn negatively regulates Y. pestis biofilm formation [ (PUBMED:24192006) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF4154