DcuC

• PFAM accession number: PF03606
• Interpro abstract (IPR018385):

  Escherichia coli contains four different secondary carriers (DcuA, DcuB, DcuC, and DctA) for C4-dicarboxylates [ (PUBMED:10482502) (PUBMED:1512189) (PUBMED:7961398) (PUBMED:8955408) ] DcuA is used for aerobic growth on C4-dicarboxylates [ (PUBMED:10482502) (PUBMED:5541510) ], whereas the Dcu carriers (encoded by the dcuA, dcuB, and dcuC genes) are used under anaerobic conditions and form a distinct family of carriers [ (PUBMED:1512189) (PUBMED:8020497) (PUBMED:9889977) (PUBMED:7961398) (PUBMED:9230919) (PUBMED:8955408) ]. Each of the Dcu carriers is able to catalyze the uptake, antiport, and possibly also efflux of C4-dicarboxylates. DcuB is the major C4-dicarboxylate carrier for fumarate respiration with high fumarate-succinate exchange activity. It is synthesized only in the absence of oxygen and nitrate and in the presence of C4-dicarboxylates [ (PUBMED:1512189) (PUBMED:9973351) (PUBMED:9852003) (PUBMED:9765574) ]. DcuA is expressed constitutively in aerobic and anaerobic growth and can substitute for DcuB [ (PUBMED:9852003) (PUBMED:7961398) ]. These proteins are members of the C4-dicarboxylate Uptake C (DcuC) family. DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalyzing fumarate-succinate exchange and fumarate uptake [ (PUBMED:8020497) (PUBMED:10368146) ]. DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates) [ (PUBMED:8955408) ].

• GO component: integral component of membrane (GO:0016021)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DcuC