The domain within your query sequence starts at position 1 and ends at position 80; the E-value for the ECM1 domain shown below is 5.2e-40.
MGTVSRAALILACLALASAASEGAFKASDQREMTPERLFQHLHEGYAAPPSPPQTRRLRV DHSVTSLHDPPLFEEQREVQ
ECM1 |
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PFAM accession number: | PF05782 |
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Interpro abstract (IPR008605): | This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis [ (PUBMED:11165938) (PUBMED:11292659) ]. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness [ (PUBMED:11929856) ]. |
GO process: | signal transduction (GO:0007165) |
GO component: | extracellular region (GO:0005576) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry ECM1