The domain within your query sequence starts at position 2 and ends at position 259; the E-value for the FAM220 domain shown below is 1.8e-75.

KAGRGTLGVCLAKQSQGGDPDKLACGLKKRSQKRNPSPSVVPSWTDQPVADSHGKSRATG
AAASEMKHGQSKASLLHHGGFKVLQSLKGSVGRSSAPAASLGKAVALSPAPSEEQLAGMS
HGIGDALGSDWPGREPRATDNRGQYLKGESWVSGRPGHPKLREVGFLRGEPPSAGPKGLG
TWSELSHRYFELGQLPYAYPYYKVLPEGELRCVSLDRFNPGLSEETVEDEKTLKFFRWSA
DSRGVTGSAIFQISKSLM

FAM220

FAM220
PFAM accession number:PF15487
Interpro abstract (IPR029155):

This domain is found in SIPAR (STAT3-Interacting Protein As a Repressor). SIPAR inhibits STAT3 activity by accelerating its dephosphorylation [ (PUBMED:23917203) ]. STAT3 is a member of the STAT family (signal transducers and activators of transcription) that plays an esential role in cell growth and differentiation.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FAM220