SMART: Pfam domain FDX-ACB

FDX-ACB

PFAM accession number:	PF03147
Interpro abstract (IPR005121):	Aminoacyl-tRNA synthetases (aaRSs) play a crucial role in the translation of the genetic code by means of covalent attachment of amino acids to their cognate tRNAs. Phenylalanine-tRNA synthetase (PheRS, also known as Phenylalanine-tRNA ligase) is known to be among the most complex enzymes of the aaRS family. Bacterial and mitochondrial PheRSs share a ferredoxin-fold anticodon binding (FDX-ACB) domain, which represents a canonical double split alpha+beta motif having no insertions. The FDX-ACB domain displays a typical RNA recognition fold (RRM) formed by the four-stranded antiparallel beta sheet, with two helices packed against it [ (PUBMED:7664121) (PUBMED:9016717) (PUBMED:10049785) (PUBMED:12962494) (PUBMED:18611382) ].

PFAM accession number:

PF03147

Interpro abstract (IPR005121):

Aminoacyl-tRNA synthetases (aaRSs) play a crucial role in the translation of the genetic code by means of covalent attachment of amino acids to their cognate tRNAs. Phenylalanine-tRNA synthetase (PheRS, also known as Phenylalanine-tRNA ligase) is known to be among the most complex enzymes of the aaRS family. Bacterial and mitochondrial PheRSs share a ferredoxin-fold anticodon binding (FDX-ACB) domain, which represents a canonical double split alpha+beta motif having no insertions. The FDX-ACB domain displays a typical RNA recognition fold (RRM) formed by the four-stranded antiparallel beta sheet, with two helices packed against it [ (PUBMED:7664121) (PUBMED:9016717) (PUBMED:10049785) (PUBMED:12962494) (PUBMED:18611382) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FDX-ACB