SMART: Pfam domain FTO

The domain within your query sequence starts at position 63 and ends at position 150; the E-value for the FTO_NTD domain shown below is 3.3e-39.

DDEFYQQWQLKYPKLVFREAGSIPEELHKEVPEAFLTLHKHGCLFRDVVRIQGKDVLTPV
SRILIGDPGCTYKYLNTRLFTVPWPVK

FTO_NTD

PFAM accession number:	PF12933
Interpro abstract (IPR024367):	This domain is the catalytic AlkB-like domain from the FTO protein [ (PUBMED:20376003) ]. This domain catalyses a demethylase activity with a preference for 3-methylthymidine. Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation [ (PUBMED:17991826) ]. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine [ (PUBMED:18775698) ]. FTO has no activity towards 1-methylguanine. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It contributes to the regulation of body size and body fat accumulation as well [ (PUBMED:19234441) ].

PFAM accession number:

PF12933

Interpro abstract (IPR024367):

This domain is the catalytic AlkB-like domain from the FTO protein [ (PUBMED:20376003) ]. This domain catalyses a demethylase activity with a preference for 3-methylthymidine.

Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation [ (PUBMED:17991826) ]. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine [ (PUBMED:18775698) ]. FTO has no activity towards 1-methylguanine. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It contributes to the regulation of body size and body fat accumulation as well [ (PUBMED:19234441) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FTO_NTD