FimH_man-bind

• PFAM accession number: PF09160
• Interpro abstract (IPR015243):

  This domain adopts a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. It is found in FimH, a mannose-specific adhesin of uropathogenic Escherichia coli strains. The domain appears to bind specifically to D-mannose and mediates cellular adhesion to mannosylated proteins, a prerequisite to colonization and subsequent invasion of epithelial tissues [ (PUBMED:12010488) (PUBMED:20507142) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FimH_man-bind