The domain within your query sequence starts at position 97 and ends at position 452; the E-value for the FimP domain shown below is 1.1e-133.



PFAM accession number:PF09766
Interpro abstract (IPR019163):

This entry represents Thoc5 which is one of the subunits of the THO complex, which additionally contains: HPR1, Thoc2, Thoc6 and Thoc7. The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes is required for the efficient expression of genes that have internal tandem repeats. It is suggested that the THO complex functions to rectify aberrant structures that arise during transcription [(PUBMED:16983072), (PUBMED:15998806)] and is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress [(PUBMED:15133499)].

This entry also identifies the crucial 144 N-terminal residues of the FMIP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes [(PUBMED:10597251)].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FimP