SMART: Pfam domain Flavi_glycop

Flavi_glycop_C

PFAM accession number:	PF02832
Interpro abstract (IPR027287):	Flaviruses are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Yellow fever virus, West Nile virus, Tick-borne encephalitis virus, Japanese encephalitis virus, and Dengue virus 2 [ (PUBMED:15378043) ]. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C ( IPR001122 ), and the envelope glycoproteins M ( IPR000069 ) and E. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Class II viral fusion proteins are found in flaviviruses and alphaviruses, and are structurally distinct from class I fusion proteins from influenza-type viruses and retroviruses. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. This entry represents the Ig-like domain III, which contains a putative receptor-binding loop [ (PUBMED:12759475) ].

PFAM accession number:

PF02832

Interpro abstract (IPR027287):

Flaviruses are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Yellow fever virus, West Nile virus, Tick-borne encephalitis virus, Japanese encephalitis virus, and Dengue virus 2 [ (PUBMED:15378043) ]. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C ( IPR001122 ), and the envelope glycoproteins M ( IPR000069 ) and E. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Class II viral fusion proteins are found in flaviviruses and alphaviruses, and are structurally distinct from class I fusion proteins from influenza-type viruses and retroviruses. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. This entry represents the Ig-like domain III, which contains a putative receptor-binding loop [ (PUBMED:12759475) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Flavi_glycop_C